How many units of FGL (FG Loop Peptide) should I draw?

It depends on your vial size, BAC water, and dose. For a 5mg vial with 2mL BAC water, a beginner dose of 1mg is typically 0 units on a U-100 syringe. Use the calculator above for your exact numbers.

How much BAC water should I add to FGL (FG Loop Peptide)?

The standard amount is 2mL of bacteriostatic water for a 5mg vial. More water gives a more dilute solution — easier to measure small doses. Less water means fewer injections per vial. Adjust the BAC water slider in the calculator to see how it changes your syringe units.

How long does a FGL (FG Loop Peptide) vial last?

At a beginner dose of 1mg 5x/week, a 5mg vial lasts about 5000 doses. The calculator shows exact doses per vial for your selected tier.

What syringe should I use for FGL (FG Loop Peptide)?

Most people use a U-100 insulin syringe (1mL / 100 units). For very small doses, a U-50 or U-30 syringe gives better precision. The calculator adjusts units automatically for whichever syringe you pick.

FGL (FG Loop Peptide) Dosage Calculator

CognitiveInjectionPhase 1~4-6 hours half-life

FGL is a synthetic pentadecapeptide corresponding to residues E681-A695 of the second fibronectin type III homology module of the neural cell adhesion molecule (NCAM).

Protects hippocampal neurons from ischemic and excitotoxic damageEnhances long-term memory consolidation in spatial and associative learningPromotes long-term potentiation (LTP) and synaptic plasticity in the dentate gyrusPromotes neurite outgrowth in dopaminergic, hippocampal, and cerebellar neurons6 weeks on / 4 weeks off

Vial Size

BAC Water (mL)

Dosing Level

1mcg · 5x/week

Custom Dose (mcg) — optional

Syringe Type

0.0 units

100 units (1mL)

Concentration

2,500

mcg/mL

Draw Volume

< 0.001

Syringe Units

< 0.1

units

Doses / Vial

5000

doses

Very small draw (< 0.1 units) — difficult to measure accurately. Consider using less BAC water for a more concentrated solution.

Try 0.5mL BAC water for an easier-to-measure draw.

Summary: Add 2mL BAC water to your 5mg vial. Draw to < 0.1 units on a U-100 syringe for a 1mcg dose. This vial will last 5000 doses.

Cycle Planner

Cycle Length (weeks)

Price Per Vial ($) — optional

Subcutaneous. Typical beginner frequency: 5x/week.

FGL (FG Loop Peptide) Pharmacokinetics

Pharmacokinetics — Active Dose Over Time

t½ = ~4-6 hours (subcutaneous administration)

After 1 half-life (5h): 50% remainsAfter 2 half-lives (10h): 25% remainsAfter 3 half-lives (15h): 12.5% remains

At a 1.5mcg dose: 50% = 1mcg remaining after 5h. Recommended frequency: 5x/week.

Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.

FGL (FG Loop Peptide) Dosing Protocol

Level	Dose / Injection	Frequency
Beginner	1mg	5x/week
Moderate	1.5mg	5x/week
Aggressive	2mg	5x/week

Note: FGL is a 15-amino-acid synthetic peptide derived from the second fibronectin type III module of the neural cell adhesion molecule (NCAM). The active clinical form is FGL(L), a dimerized version consisting of two FGL monomers linked together, which provides better blood-brain barrier penetration. A Phase I clinical trial has confirmed tolerability and safety of intranasal FGL(L) in healthy volunteers at doses up to 200 mg. Always source the dimerized FGL(L) form rather than the monomer for optimal CNS activity.

About FGL (FG Loop Peptide)

FGL is a synthetic pentadecapeptide corresponding to residues E681-A695 of the second fibronectin type III homology module of the neural cell adhesion molecule (NCAM). It was designed to mimic the specific region of NCAM that binds and activates fibroblast growth factor receptor 1 (FGFR1), making it a targeted FGFR1 agonist with potent neurotrophic and neuroprotective properties. Research on FGL spans over two decades and includes both preclinical and early clinical work. In rodent models of ischemic stroke, a single suboccipital injection of FGL given 24 hours before induced global ischemia significantly protected hippocampal CA1 neurons from death. The peptide also preserves metabolic function and presynaptic activity in hippocampal slice cultures exposed to oxygen-glucose deprivation, whether applied before or after the insult. FGL's cognitive benefits are among its most compelling features. Intracerebroventricular administration immediately after training in fear conditioning or water maze tasks produced long-lasting memory improvements persisting up to one month in rats. The peptide enhances long-term potentiation (LTP) in the dentate gyrus of freely moving animals, with effects lasting up to 24 hours — the first demonstration that mimicking the NCAM-FGFR interaction promotes hippocampal synaptic plasticity in vivo. Beyond neuroprotection and memory, FGL mobilizes endogenous neural stem cells from the subventricular zone and hippocampus after stroke, promoting remyelination and modulating neuroinflammation through microglial regulation. A Phase I clinical trial using intranasal FGL(L) at doses up to 200 mg in healthy volunteers confirmed tolerability with dose-proportional systemic exposure and detectable brain penetration.

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