Peptide Schedule Research TeamReviewed Apr 202611 Citations
Endomorphin-1 & Endomorphin-24 residuesYPWFEach bubble = one amino acid. Size = residue mass. Color = chemical class.Adjust vial, water, and dose — answer updates live
on a U-100 syringe for a 50mcg dose
Never miss a dose — 50mcg single dose, draw 10.0 units on U-100 syringe.
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Endomorphin-1 and Endomorphin-2 are the body's own mu-opioid receptor agonists, binding with selectivity no other endogenous peptide matches. Still research-only, with a plasma half-life measured in minutes. CYT-1010, a stabilized analog, showed analgesia without respiratory depression in Phase I trials.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 50mcg | Single dose |
| Moderate | 100mcg | Single dose |
| Aggressive | 250mcg | Single dose |
This is a research reagent, not a consumer peptide. No standard vial exists at peptide vendors. If you're sourcing from a scientific supplier (GenScript, Bachem, AAPPTec), typical custom synthesis delivers 1 mg lyophilized. Add 2 mL bacteriostatic water for 500 mcg/mL. At that concentration, a 50 mcg dose pulls 10 units on a standard insulin syringe; 100 mcg pulls 20 units; 250 mcg pulls 50 units. Those doses are entirely speculative. No published human pharmacokinetic data supports any peripheral SC dose for native endomorphin. The Tyr-Pro bond gets cleaved by DPP-IV in minutes, and barely anything crosses the blood-brain barrier from a peripheral route. Swirl gently after reconstitution. Don't vortex. C-terminal amidation is what keeps these peptides binding MOR; rough handling won't help stability. Store lyophilized at -20C desiccated. Reconstituted, you get maybe 7 days at 2-8C. Prepare small aliquots and minimize freeze-thaw cycles. Request a CoA confirming sequence (EM-1: Tyr-Pro-Trp-Phe-NH2 or EM-2: Tyr-Pro-Phe-Phe-NH2) with HPLC purity at least 95% and mass spec verification.
Dosing based on Very limited human data: dose based on preclinical opioid receptor research — 17 published references.View all sources →
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Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
