Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 202610 Citations
Dermorphin7 residuesYAFGYPSEach bubble = one amino acid. Size = residue mass. Color = chemical class.Dermorphin is a frog-derived opioid peptide with 30-40x morphine's analgesic potency. One 1985 human RCT showed superiority over morphine for postoperative pain; no further clinical trials exist. Likely classified as a Schedule I analog under US federal law. Research reference only, not for human use.
50mcg · Single dose
Summary: Add 2mL BAC water to your 1mg vial. Draw to 10.0 units on a U-100 syringe for a 50mcg dose. This vial will last 20 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 50mcg | Single dose |
| Moderate | 100mcg | Single dose |
| Aggressive | 200mcg | Single dose |
Dermorphin is not a self-use peptide. It's listed as a research reference because its pharmacology is genuinely interesting, but the risk profile makes it wholly inappropriate for self-administration. If you're handling this in a research context, the reconstitution math works like this. A 1 mg vial reconstituted with 1 mL bacteriostatic water gives a 1 mg/mL (1,000 mcg/mL) solution. On a U-100 insulin syringe, each unit equals 10 mcg. So 50 mcg is 5 units, 100 mcg is 10 units, 200 mcg is 20 units. The thing most people miss: plasma half-life (~1.3 min in rodents, ~5.4 min in horses) does not equal duration of action. Receptor binding and beta-arrestin-mediated internalization sustain the analgesic effect for 45-90 minutes IV, and up to 48 hours intrathecally. Don't confuse clearance from blood with clearance from the receptor. Naloxone on hand is non-negotiable. Analytical-grade sourcing with LC-MS/MS purity verification is also non-negotiable.
Dosing based on Preclinical data only: no human dosing established — 19 published references.View all sources →
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Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Dermorphin is a frog-derived opioid peptide with 30-40x morphine's analgesic potency. One 1985 human RCT showed superiority over morphine for postoperative pain; no further clinical trials exist. Likely classified as a Schedule I analog under US federal law. Research reference only, not for human use.
