Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 202611 Citations
Argireline is a topical hexapeptide that inhibits SNARE complex assembly to soften expression wrinkles. Clinical results range from 48.9% efficacy to no significant effect across controlled trials. At $10 per bottle, it's worth testing on your own skin before drawing conclusions.
2mcg · 2x Daily
Summary: Add 0mL BAC water to your 5mg vial. Draw to < 0.1 units on a U-100 syringe for a 2mcg dose. This vial will last 0 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 2mg | 2x Daily |
| Moderate | 5mg | 2x Daily |
| Aggressive | 10mg | 2x Daily |
Start with a 5% concentration for the first two weeks if your skin runs reactive. One study landed on nearly identical wrinkle reduction at 5% vs. 10% (16.26% vs. 17%), so you're not losing much during the tolerance phase. After that, step up to 10% twice daily. Argireline is a topical peptide, not an injectable. There's no vial to reconstitute, no bacteriostatic water, no syringe math. You're buying a ready-to-use serum or cream. The Ordinary's 10% solution at $10 for 30ml is the community benchmark; use it to calibrate your expectations before spending more on premium formulations. The thing most beginners miss: check the label carefully. Some products list "contains Argireline" when the peptide is a trace ingredient in a blend. You want 10% Acetyl Hexapeptide-8 as the active, listed early in the INCI order. Apply to clean, dry skin before moisturizer. Morning and evening. Give it 2 to 3 minutes to absorb before layering. Refrigerate opened bottles and use within six months.
Dosing based on Cosmeceutical industry standard concentrations — 15 published references.View all sources →
Cross-check your Argireline reconstitution math with AI
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Argireline is a topical hexapeptide that inhibits SNARE complex assembly to soften expression wrinkles. Clinical results range from 48.9% efficacy to no significant effect across controlled trials. At $10 per bottle, it's worth testing on your own skin before drawing conclusions.