How many units of Amylin (IAPP) should I draw?

It depends on your vial size, BAC water, and dose. For a 1mg vial with 2mL BAC water, a beginner dose of 10mcg is typically 2 units on a U-100 syringe. Use the calculator above for your exact numbers.

How much BAC water should I add to Amylin (IAPP)?

The standard amount is 2mL of bacteriostatic water for a 1mg vial. More water gives a more dilute solution — easier to measure small doses. Less water means fewer injections per vial. Adjust the BAC water slider in the calculator to see how it changes your syringe units.

How long does a Amylin (IAPP) vial last?

At a beginner dose of 10mcg 3x daily, a 1mg vial lasts about 100 doses. The calculator shows exact doses per vial for your selected tier.

What syringe should I use for Amylin (IAPP)?

Most people use a U-100 insulin syringe (1mL / 100 units). For very small doses, a U-50 or U-30 syringe gives better precision. The calculator adjusts units automatically for whichever syringe you pick.

Can native amylin cause local amyloid deposits at injection sites?

Yes. Chronic subcutaneous amylin administration in preclinical models has produced local amyloid deposition at injection sites, a direct consequence of the amyloidogenic region (residues 20–29) aggregating at the site. This risk does not exist with pramlintide or cagrilintide.

Why is cagrilintide dosed weekly while pramlintide requires three daily injections?

Half-life engineering. Pramlintide: ~48 min. Native amylin: ~13–20 min. Cagrilintide: ~7 days. Novo Nordisk used the same fatty acid chain + linker technology that made semaglutide weekly; binding to albumin dramatically slows renal clearance and proteolytic degradation.

Not medical advice. Talk to your provider before using any peptide.

Full disclaimer

Peptide Schedule Research TeamReviewed Apr 20269 Citations

MetabolicResearchGrade C

AmylinIAPPResearch PeptideAmyloid

Amylin (IAPP) Dosage Calculator

~13-22 minutes half-life·Injection

Amylin (IAPP) is the pancreatic hormone behind pramlintide and cagrilintide. Thirty-seven amino acids, co-secreted with insulin, toxic when it misfolds. Research-only peptide with well-characterized glucose and satiety signaling but no safe path to clinical use in its native form.

NicheModerate4,073Moderate

13 referencesVerified 2026-04-07

Vial Size

BAC Water (mL)

Dosing Level

10mcg · 3x Daily

Custom Dose (mcg) — optional

Syringe Type

2.0 units

100 units (1mL)

Concentration

500

mcg/mL

Draw Volume

0.020

Syringe Units

2.0

units

Doses / Vial

100

doses

Very small draw (2.0 units) — difficult to measure accurately. Consider using less BAC water for a more concentrated solution.

Try 1mL BAC water for an easier-to-measure draw.

Summary: Add 2mL BAC water to your 1mg vial. Draw to 2.0 units on a U-100 syringe for a 10mcg dose. This vial will last 100 doses.

Schedule This Protocol

10mcg 3x daily — draw 2.0 units on U-100 syringe

Subcutaneous. Typical beginner frequency: 3x daily.At beginner dose (10mcg) with a 1mg/2mL vial: draw to the 2-unit mark on a U-100 syringe.

After reconstituting, store at -20°C (lyophilized); 2-8°C (reconstituted, use immediately) (refrigerate — use within 24-48 hours when stored at 2-8°c. native amylin aggregates rapidly in solution: prepare fresh and use immediately for research applications. acidic ph (< 4.0) or hfip pre-treatment can delay aggregation.).

View side effects and safety warnings →

Quick-Start: Reconstitution

1Pull your lyophilized IAPP vial from -20C storage. Let it reach room temperature (5 to 10 minutes).
2Prepare acidic reconstitution buffer (sterile water adjusted to pH 3 to 4). Do not use standard bacteriostatic water at neutral pH.
3Add 2 mL of acidic buffer to a 1 mg vial. Swirl gently until dissolved. Do not shake. This gives you 500 mcg/mL.

Full injection guide →

Amylin (IAPP) Dosing Protocol

SpeculativeResearch peptide; pramlintide (Symlin) is the clinical analog: dose not interchangeable

Level	Dose / Injection	Frequency
Beginner	10mcg	3x Daily
Moderate	25mcg	3x Daily
Aggressive	50mcg	3x Daily

Note:

This is a research reagent, not a therapeutic peptide. If you're looking for amylin replacement therapy, pramlintide (Symlin) is the FDA-approved option with three proline swaps that stop aggregation. Reconstitution math for a 1 mg vial: add 2 mL acidic buffer (pH 3 to 4). That gives you 500 mcg/mL. At 10 mcg per dose, each injection is 0.02 mL, which is 2 units on a U-100 insulin syringe. At 25 mcg, it is 5 units. At 50 mcg, it is 10 units. For a 5 mg vial with 2 mL, you get 2,500 mcg/mL; 50 mcg would be 0.02 mL (2 units). Use the 1 mg vial for research dosing accuracy. The thing most beginners miss: you cannot reconstitute native IAPP in standard bacteriostatic water at neutral pH. Aggregation begins within hours. You need acidic buffer (pH 3 to 4), or HFIP pre-treatment. Dissolve in hexafluoroisopropanol, lyophilize into aliquots, reconstitute fresh. Prepare only the volume you need right before use. Discard anything with haziness or particulates; that is aggregated IAPP, and it is both inactive and cytotoxic.

Dosing based on Research peptide; pramlintide (Symlin) is the clinical analog: dose not interchangeable — 13 published references.View all sources →

Verify your calculation

Cross-check your Amylin (IAPP) reconstitution math with AI

Amylin (IAPP) Cost

Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →

Amylin (IAPP) Pharmacokinetics

Pharmacokinetics — Active Dose Over Time

t½ = ~13-22 minutes

After 1 half-life (18m): 50% remainsAfter 2 half-lives (35m): 25% remainsAfter 3 half-lives (53m): 12.5% remains

At a 25mcg dose: 50% = 13mcg remaining after 18m. Recommended frequency: 3x Daily.

Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.