Peptide Schedule
Alpha-MSH (α-Melanocyte-Stimulating Hormone)13 residues (approx.)SYSMEHFRWGKPVEach bubble = one amino acid. Size = residue mass. Color = chemical class.Uses closest standard amino acids for non-standard residues.Alpha-MSH (α-Melanocyte-Stimulating Hormone) Dosage Calculator
Alpha-melanocyte-stimulating hormone (alpha-MSH) is a 13-amino-acid neuropeptide produced by cleavage of proopiomelanocortin (POMC) in the pituitary gland, hypothalamus, keratinocytes, and immune cells.
100mcg · Daily
Summary: Add 2mL BAC water to your 1mg vial. Draw to 20.0 units on a U-100 syringe for a 100mcg dose. This vial will last 10 doses.
Cycle Planner
Alpha-MSH (α-Melanocyte-Stimulating Hormone) Pharmacokinetics
Pharmacokinetics — Active Dose Over Time
t½ = ~20 minutes (rapid proteolytic degradation)Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Alpha-MSH (α-Melanocyte-Stimulating Hormone) Dosing Protocol
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 100mcg | Daily |
| Moderate | 250mcg | Daily |
| Aggressive | 500mcg | Daily |
Note: Alpha-MSH is a 13-amino-acid endogenous peptide (Ac-SYSMEHFRWGKPV-NH2) derived from post-translational processing of proopiomelanocortin (POMC). It is one of the most potent endogenous anti-inflammatory mediators known, acting through melanocortin receptors MC1R through MC5R with varying affinities. The C-terminal tripeptide KPV retains much of the anti-inflammatory activity without melanogenic effects. Native alpha-MSH has an extremely short plasma half-life due to rapid enzymatic degradation, which has driven development of synthetic analogs such as afamelanotide (Scenesse) and setmelanotide (Imcivree). Research use only in its native form.
About Alpha-MSH (α-Melanocyte-Stimulating Hormone)
Alpha-melanocyte-stimulating hormone (alpha-MSH) is a 13-amino-acid neuropeptide produced by cleavage of proopiomelanocortin (POMC) in the pituitary gland, hypothalamus, keratinocytes, and immune cells. First characterized for its role in stimulating melanin production in melanocytes, alpha-MSH has since been recognized as a central mediator of inflammation, immune regulation, energy homeostasis, and appetite control. It signals through the melanocortin receptor family (MC1R-MC5R), G-protein coupled receptors that activate adenylyl cyclase and increase intracellular cAMP. MC1R activation on immune cells drives its potent anti-inflammatory effects, while MC4R signaling in the hypothalamus regulates satiety and energy expenditure. Alpha-MSH has demonstrated efficacy in numerous preclinical models of inflammation including colitis, arthritis, brain ischemia, organ transplant rejection, allergic inflammation, and fibrosis. Its anti-inflammatory potency exceeds many conventional agents in animal models. The discovery that the C-terminal tripeptide KPV (Lys-Pro-Val) retains anti-inflammatory signaling without melanogenic or appetite-suppressive effects has opened avenues for targeted therapeutic development. Clinically, the melanocortin pathway has been validated through FDA approval of setmelanotide (Imcivree) for MC4R-related obesity and afamelanotide (Scenesse) for erythropoietic protoporphyria, confirming the druggability of this receptor system. Native alpha-MSH remains a research-only compound due to its short half-life and broad receptor activity.